Monobactams Accession Number DBCAT000782 Description. Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized. ATC Classification. J — ANTIINFECTIVES FOR SYSTEMIC USE; J01 — ANTIBACTERIALS FOR SYSTEMIC USE.
Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. It is given by injection into a vein or muscle or breathed in as a mist.
Aztreonam is a parenterally administered, synthetic monobactam antibiotic that is specifically active against aerobic gram-negative bacilli is resistant to many beta-lactamases. Aztreonam therapy is often accompanied by mild, asymptomatic elevations in serum aminotransferase levels, but it has not been reported to cause clinically apparent liver injury.
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The classification mentioned could be a better guide for future classification, i.e. the agents that are in developing stages or those that are going to develop can be adjusted in any suitable group mentioned in the text. Further, this categorization could be helpful in academic and in health care fields at present and in the future as well.
An elevated extended-spectrum cephalosporin or monobactam MIC is not definitive evidence of the presence of an ESBL. However, screening for the ESBL phenotype is an important tool, even in countries in which the prevalence of ESBLs is low. ESBLs provide an important mechanism of resistance in gram-negative organisms. Clinical microbiology laboratories, hospital epidemiologists, and clinicians.